The cupcakes appear as white-frosted cupcakes in black cupcake liners with pieces of black licorice on top of them. They seem to be very disgusting and dull-tasting, probably because Major Nixel bakes them. However, he declares them perfect thanks to the Nixels' belief that uncreativity is a good thing. It is known that Gobba dislikes his cupcakes, and other Mixels probably do as well.
Orbiton cupcakes, on the other hand, seem more appealing then their counterpart. They are lemon-frosted with pink cupcake liners and orange sprinkles on them. They are also somewhat taller than Nixel cupcakes.
Cupcakes first appeared in Calling All Mixels as a weapon that the Nixels use. Cannon Nixels have them as their ammo and shoot them with the push of a button. They can travel far distances and deal a lot of damage to the Mixels that get hit by them.
Major Nixel, too tired to follow his Nixels in capturing the Mixel tribe leaders, heads back to the Mix Festival to bake cupcakes. As soon as the color and the cubits are restored, he finishes and announces what he says are "perfect cupcakes". The Gobba & Flain Mix samples them, declaring that something is missing: Major Nixel's face. He flips the table, smashing the cupcakes into the major's face.
Nurp-Naut and the Orbitons had baked fresh cupcakes to go with the other refreshments at the Infernites' welcoming party on Mixel Moon. However, it didn't take long for Burnard to find them and eat them all in one bite, along with the cups for Oxy-Juice.
- They are the only food to have been made by Nixels. However, the Mixels still have their own variation of them as well.